VCU Research Shows Erectile Dysfunction Drug Reduces Death Of ...
Posted by ~Ray @ 2007-12-12 22:15:21
The results are a key finding that may help researchers develop a new treatment for patients with heart failure where the loss of cells is primarily due to cell suicide.
In the Journal of Biological Chemistry published online Jan. 24. VCU researchers open that treatment with Viagra generically known as sildenafil citrate at clinically relevant concentrations produced therapeutic levels of nitric oxide (NO) in the heart cells of mice by increasing protein levels of two enzymes responsible for the synthesis of NO.
Employing a cellular model where heart attack-like conditions are simulated in a Petri cater they that NO produced from sildenafil inhibits cell death by stabilizing mitochondria increasing the level of the anti-death protein. Bcl-2 and inhibiting caspase 3 the protein considered to be the ultimate weapon in cell suicide.
“This investigate has established a strong basis for the create by mental act of future studies targeted toward investigating the clinical effects of sildenafil on survival of heart muscle following a study heart attack,” said Rakesh C. Kukreja. Ph. D. professor of medicine physiology and biochemistry at VCU and lead compose of the chew over.
“In addition these findings declare that this drug may slow or possibly reverse the progressive loss of heart cells during chronic heart failure in patients with coronary artery disease,” he said.
Researchers used heart cells prepared from genetically engineered mice that lack nitric oxide synthesizing enzymes. The model was particularly useful in studying the protective cause of sildenafil in heart go across cells independent of any vascular effects or other types of cells. Kukreja said.
According to Kukreja sildenafil not only protected against necrosis accidental cell death occurring due to oxygen deprivation but also against apoptosis cell death following DNA fragmentation. Furthermore the researchers open the presence of phosphodiesterase-5 (PDE-5) an enzyme responsible for the destruction of the cGMP molecule in the heart cells. The cGMP is an messenger molecule that plays an important role in the dilation of arteries in the be. Sildenafil is able to preserve cGMP and therefore dilation of the arteries by inhibiting PDE-5.
“These observations have far-reaching implications for the treatment of patients with heart failure where loss of cells is primarily due to apoptosis,” he said.
Kukreja and his colleagues began studying sildenafil in 2002 as part of an on-going research program into “preconditioning,” which is a way to defend the heart muscle from serious damage in the future by depriving it for very apprise periods of blood flow and therefore oxygen. In papers published in the September 2002 issue of the American Journal of Physiology and the walk 2003 issue of Circulation Research. Kukreja and his colleagues observed a powerful protective effect of sildenafil in the heart during heart attack in animal models.[ADVERTHERE]Related article:
http://erectiledysfunctionn.placemeonline.com/2007/11/15/vcu-research-shows-erectile-dysfunction-drug-reduces-death-of-heart-cells-in-heart-attack-model/
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